This study is aimed at the development and endorsement of a methodology for the identification of cluster formations from a territorial-economic perspective. Aim. This study aims to develop a cluster identification methodology based on such indicators as “leadership” and “propulsion.” Tasks. This study develops and endorses a new methodological approach to identify cluster formations within a region based on cluster classifications into “neutral,” “overtaking,” and “propulsive” and analyzes the dynamic development of various types of economic activities in the regions of the Central Federal District (CFD). Methodology. This study uses general methods of scientific cognition, economic-mathematical modeling, and statistical analysis to develop approaches to identify various cluster types. Results. A proprietary methodology for cluster identification based on an iterative approach is produced, and cluster groups are identified from an industrial perspective through the example of the CFD regions. Conclusion. Activation of propulsive clusters in regions and the implementation of a selective funding policy is particularly important during an economic downturn.